Plants utilize intricate signaling networks to coordinate responses based on internal and external cues. During this session, the molecular mechanisms of signal perception, transduction, and integration in various pathways will be addressed. Speakers will present hormonal crosstalk between auxins, gibberellins, cytokinins, abscisic acid, and ethylene, demonstrating how signals from more than one converge to control growth and stress adaptation. Case studies will illustrate signaling under drought, salinity, and pathogen attack, highlighting the dynamic interaction among environmental inputs and cellular responses. New developments in live-cell imaging, proteomics, and computational modeling of signaling networks will be highlighted. Participants will also discuss synthetic biology tools to reprogram signaling pathways for enhanced crop stress resistance. Unveiling the complexities of plant communication at the cellular and molecular levels, this session promises a holistic appreciation of the processes that underpin plant survival, development, and productivity.